Currently, there are three groups working with cryo-EM at IST Austria. Follow the links to learn more about their research.
Bernecky Group – RNA-Based Gene Regulation
The regulated expression of genetic material is one of the most basic processes of a cell, affecting everything from organism development to environmental response. Through structural studies of the involved complexes, the Bernecky group works to unravel the gene expression regulatory networks that employ RNA as an intermediate.
Sazanov Group – Structural Biology of Membrane Protein Complexes
Membrane proteins are responsible for many fundamental cellular processes including the transport of ions and metabolites, energy conversion, and signal transduction. They are the target of about two thirds of modern drugs. However, membrane proteins, especially large complexes, are challenging for structural studies and so are underrepresented in structural databases.
Schur Group – Structural Biology of Cell Migration and Viral Infection
The Schur group uses advanced cryo-electron tomography and image processing methods to study the structure and function of protein complexes in situ. The group focuses on the dynamic actin cytoskeleton, the key player in the ability of cells to move. In addition, the group develops cryo-electron tomography and subtomogram averaging tools using retroviruses as model systems, also trying to answer important questions in conservation and diversity of retroviral capsids.